My standard approach is to use 2nd order centered difference for the main part of the vector, and use first order forward and backward difference at the boundaries:
function d = cdiff(x, dt)
if (nargin<2)
dt =1 ;
end
d(1) = (x(2) - x(1)) / dt;
d(length(x)) = ( x(end) - x(end-1) ) / dt;
ndx = 2:(length(x)-1);
d(ndx) = (x( ndx+1) - x(ndx-1)) / (2 * dt);