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If you want to determine noise type with kurtosis, skewness, do you calculate from background (since foregrounds may include tumors) ???

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Hi,
I want to evaluate kurtosis and skewness features of images.
I want to calculate kurtosis and skewness to determine the noise type in medical images, which inlcude lesions.
Should I do the calculations from background ? Or, should the calculation make from randomly chosen regions ? or, what is your suggestion?

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