How can I remove the circles(different colours) from the dermoscopic image?

My dataset contains a variety of noise. One noise is in the form of different shapes(circles) of different sizes and colors at different locations. How can I remove them? Please give me some guidelines or some hints/code from where to start. Please see the attached image. I will be really thankful

[Meghana Dinesh]

I'm not clear what you want to remove. Are the red/yellow/green.. circles noise?

[Image Analyst]

What, exactly, does "remove" mean to you? Do you want to crop out a smaller rectangular region that doesn't have the circles? Do you want to blacken/whiten the circles? Do you want to replace them with a uniform skin tone color?

[Nazia Hameed]

Yes, the yellow, red, green circles are noise. First I want to detect them and remove them by replacing them with skin color.

[Image Analyst]

Why? Have you used the color Thresholder on the Apps tab, or seen my color segmentation demos http://www.mathworks.com/matlabcentral/fileexchange/?term=authorid%3A31862&sort=downloads_desc

[Nazia Hameed]

ok. Thank you, I will have a look. I tried color segmentation and getting initial results. Thank so much.

[Nazia Hameed]

I have tried and I generated a mask. Can you plz tell me how can I fill the holes? I have tried your code available on https://uk.mathworks.com/matlabcentral/answers/195337-i-want-to-fill-some-small-holes-into-black-because-the-whole-shape-is-black-but-there-are-some-irreg But its not working. I have also tried imfill function. for filling holes I am writing the below code

% 
smallestAcceptableHoleSize = 4000; % in pixels.
fillimage2 = bwareaopen(fillimage, smallestAcceptableHoleSize);
subplot(4, 4, 13);
imshow(fillimage2, []),title('Fill Image');

Answer 1

[Selva Karna]

first separate region based object, after that apply contour , further apply binary selection .

Answer 2

[Image Analyst]

What I'd do is to threshold the saturation channel since the colored circles have much higher saturation than the skin. Attached is a demo.

[Nazia Hameed]

First of all Thank you so much for your time you are spending to help me. I am really really thankful to you and may you have the best of all the things. I tried your code but this is also detecting the area of interest. All I want is to create a generic code/algo that can be applied on all the images (with circles/without circles) with different types of diseases. The benign cancer is really small but the malignant cancer are really large in size and also the colour is different. When I apply the one developed by you as well as by me it detects the region of interest too. Please see attached picture. is there any way I can detect using shape?

once again thank you so much.