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This project presents a SimBiology implementation of a physiologically-based pharmacokinetic (PBPK) model for trichloroethylene (TCE) and its metabolites. It is based on the article, “A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol” by Fisher et al. [1].
The human PBPK model for TCE and its metabolites presented here was developed by Fisher et al. [1] in order to assess human health risks associated with low level exposure to TCE. TCE is a commonly used solvent in the automotive and metal industries for vapor degreasing of metal parts. Exposure to TCE has been associated with toxic responses such as cancer formation and brain disorders in rodents and in humans [1]. In this PBPK model, TCE enters the systemic circulation through inhalation. Its disposition is described by a six-compartment model representing the liver, lung, kidney, fat, and slowly perfused and rapidly perfused tissues. In the liver, TCE is metabolized to trichloroacetic acid (TCA) and free trichloroethanol (TCOH-f) via P450-mediated metabolism where a fraction of TCOH-f is converted to TCA. For simplicity, a four-compartment submodel was used to describe the disposition of metabolites, TCA and TCOH-f, in the lung, liver, kidney, and body (muscle). Both metabolites are described to be excreted in the urine. TCOH-f is glucuronidated in the liver, forming glucuronide-bound TCOH (TCOH-b), and excreted in the urine via a saturable process whereas TCA is excreted by a first-order process by the kidney.

Reference: Fisher, J. W., Mahle, D., & Abbas, R. (1998). A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol. Toxicology and applied pharmacology, 152(2), 339-359.
- matrix1, matrix2, matrix3, matrix4, ...
- test_20kmh, test_50kmh, test_80kmh, ...
- nameA, nameB, nameC, nameD,...
- Slow
- Buggy
- Security Risk
- Difficult to Work With
- Obfuscated Code Intent
- Confuses Data with Code
- Code Helper Tools do not Work
- Magically Making Variables Appear in a Workspace is Risky
- Indexing into Cell Array or ND-Array
- Non-scalar Structures (with Indexing)
- Dynamic Field-Names in a Structure
- load into a Structure, not into the Workspace
- save the Fields of a Scalar Structure
- Use a table or timetable Array
- Use more Efficient Ways to Pass Variables Between Workspaces
Apologies for putting this question here, but I'm not sure there's a specific forum for Cody-related questions.
I recently noticed that a new badge for "Magic Numbers Master" had been created and awarded. When I entered my profile to check that out, I noticed that I had received that badge, but lost the badge for "Cody Challenge Master." I thought that maybe my solution had been messed up because of a change in one of the test suites that my solution missed, as this has happened a number of times on other problems. According to the text underneath the badge icon, I've still solved all 96 of the questions in the Cody Challenge. All of the problems listed as part of that challenge are still marked as "Solved." Has anyone else run into this issue?