dose dependence in simbiology model

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Anne Smith
Anne Smith on 27 Jan 2022
Answered: Arthur Goldsipe on 28 Jan 2022
I was wondering if anyone was aware of an example online of how to incorporate dose-dependent absorption in a simbiology model?
I am using the 2021a GUI.
Many thanks, Anne

Answers (1)

Arthur Goldsipe
Arthur Goldsipe on 28 Jan 2022
I think the answer depends on how, mathematically, you want to model dose-dependent absorption. You can easily create various PK models in SimBiology, as described here. One of the options for this is to model elimination with Michaelis-Menten kinetics. This would create dose-dependent elimination.
If that doesn't meet you needs, please share more details about how (mathetmatically) you want to model dose-dependent absorption.
I hope that helps.
-Arthur

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