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How to create binary image mask if my data image have multiple lesion in 1 image?

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Dayangku Nur Faizah Pengiran Mohamad
My question is, how can I create binary mask if my image data have multiple lesion in 1 image?
Below I shared examole of my single lesion (already in binary mask);
According to the codes I wrote, it is drawn by free hand.
Below I shared my multiple lesion image data:

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